Dustin Leale
Thank you for stopping by.
I am a researcher with a PhD in Integrative Pathobiology, I am interested in the role of the immune system in disease development.
Experience
Postdoctoral Researcher, Prinses Maxima Centrum voor Kinderoncologie (2024-2025)
Investigating the genetic links between late secondary effects of chemotherapies and cellular senescence in the Van Boxtel Group. Through the use of primary patient tissues and single cell genomics and transcriptomics we are searching for off-target effects of cancer therapies and genetic ties to cellular senescence.
PhD Candidate Researcher (2022-2023)
My PhD work in the Haudenschild Lab was at the intersection of Immunology and Osteoarthritis. I have extensive experience working with animal models and translational research, combining in-vivo and primary cell in-vitro models and assays. This work characterized inflammation in the early hours of injury response tissues using animal injury models and single-cell sequencing. I helped elucidate the role of injury and subsequent inflammation in the development of osteoarthritis.
Research Analyst, University of California School of Veterinary Medicine, Davis (2018)
During this work in the Gilor Lab I split time between wet lab research, training students and basic database analysis. Working on characterizing the pharmacodynamics of new insulin compounds in felines, as well as immunohistochemical analysis of pancreatic islets. Database work correlated diabetic diagnosis with earlier patient lab data.
Junior Specialist (2013-2017)
I worked across several labs as a junior specialist before pursuing my PhD. In Dr. Boaz Arzi’s lab I helped establish a new lab, developing SOPs, trained students and learned many techniques from SEM to radiography, cell culture, biochemical assays and mechanical testing. This work characterized joint pathologies in wild animal populations as well as assessed surgical techniques in the veterinary field. With the Borjesson lab I worked with immune cells, performed ELISA’s and flow cytometery to support stem cell therapies. Finally with Dr. Derek Cissell I developed mechanical testing protocols, captured MRIs, biochemical assays, supported grant writing and trained students, this work helped correlate MRI imaging with underlying biology in osteoarthritic tissues.
Education
PhD in Integrative Pathobiology (2023)
University of California at Davis
During my PhD I studied the role of innate immune signalling in the pathogenesis of early osteoarthritis. Injury to a join is a distinct predictor of developing post-traumatic osteoarthritis. Inflammation continues to damage difficult to repair joint tissues after trauma, over time this accumulation of damage leads to joint dysfunction and pain. My work used an acute injury model in mice to study the critical early changes that cells within the joint experience.
Bachelor’s of Science in Exercise Biology (2011)
University of California at Davis
My bachelors focused on the biological processes that underlie our physiological activities. From biomechanics and anatomy to basic biochemistry and metabolism.
Skills
- Animal Models 7+ Years
- Immunology 5+ Years
- Biochemistry 7+ Years
- Molecular biology 4+ Years
- Bioinformatics 4+ Years
- Computational 4+ Years
- Visualization 7+ Years
Interests
Nature
I love getting outdoors and enjoying nature, from a hike to a long backpacking trip – it’s my Happy Place.
Computers
Since I was a kid I have always enjoyed tinkering and playing with computers, have built several systems now from a home media PC to my last few desktops. I enjoy the modularity and playing games such as Factorio.
Woodworking
Being able to craft something is wonderful, I love wood as a sustainable and reusable material with very interesting and beautiful properties.
